Dose intensity for conditioning in allogeneic hematopoietic cell transplantation: can we recommend “when and for whom” in 2021?
نویسندگان
چکیده
منابع مشابه
Allogeneic hematopoietic stem cell transplantation (HSCT) after reduced intensity conditioning.
Allogeneic hematopoietic stem cell transplantation (HSCT) following myeloablative (conventional) conditioning regimen is associated with a high incidence of transplant-related morbidity and mortality, limiting its use to younger patients without medical co-morbidities. Over the past few years, it has become more evident that the alloreactivity of transplanted donor immunocompetent cells against...
متن کاملReduced-intensity conditioning allogeneic stem cell transplantation in HIV patients with hematologic malignancies: yes, we can.
4 hours after the snake bite, when there has been ample time to exhaust endogenous clotting factors.3 Furthermore, the rate of recovery (based on INR) after antivenom treatment is expected to correlate with resynthesis of the consumed clotting factors. Notably, no reference was made to prothrombin levels after envenomation.3 We speculate that this information could provide greater insight into ...
متن کاملreduced intensity versus full myeloablative conditioning in allogeneic stem cell transplantation for acute myeloid leukemia
introduction: allogeneic hematopoietic stem cell transplantation (hsct) has been reported to be a successful curative treatment in aml patients. myeloablative conditioning (mac) is used more frequent as a preparing regimen. this study attempts to compare the outcome of patients who has received mac and reduced- intensity conditioning (ric). methods: totally, 618 patients with aml underwent hsct...
متن کاملCurrent roles for allogeneic hematopoietic cell transplantation following nonmyeloablative or reduced-intensity conditioning.
Nonmyeloablative and reduced-intensity conditioning regimens followed by allogeneic hematopoietic cell transplantation (HCT) have been evaluated in patients with hematologic malignancies who were not considered candidates for conventional HCT because of age or medical comorbidities and in selected patients with metastatic renal cell carcinoma. The regimens have relied more on graft-versus-tumor...
متن کاملA comparison between low intensity and reduced intensity conditioning in allogeneic hematopoietic stem cell transplantation for solid tumors.
BACKGROUND Following different types of conditioning, allogeneic hematopoietic stem cell transplantation produces a graft-versus-tumor effect in patients with solid tumors. We performed a non-randomized study comparing low intensity conditioning with reduced intensity conditioning after stem cell transplantation to demonstrate the graft-versus-tumor effect. DESIGN AND METHODS Allogeneic stem ...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2021
ISSN: 1592-8721,0390-6078
DOI: 10.3324/haematol.2020.268839